Research Articles
Harnessing Genetic Algorithms for Advanced Metabolic Strain Design: From Foundations to Future Frontiers
This article provides a comprehensive overview of genetic algorithms (GAs) for optimizing microbial strain designs in metabolic engineering.
CRISPRi Screening for Metabolic Pathway Optimization: A Comprehensive Guide from Foundational Concepts to Advanced Applications
This article provides a comprehensive overview of CRISPR interference (CRISPRi) screening for optimizing metabolic pathways in microbial hosts.
Inverse Metabolic Engineering and Metabolic Control Analysis: A Synergistic Framework for Advanced Bioproduction and Drug Discovery
This article provides a comprehensive analysis of the synergistic relationship between inverse metabolic engineering (IME) and metabolic control analysis (MCA) for researchers and drug development professionals.
Integrating Omics Data into Metabolic Network Models: Principles, Methods, and Applications in Biomedicine
The integration of multi-omics data into genome-scale metabolic models (GEMs) is revolutionizing systems biology and precision medicine.
Strategic Host Chassis Selection for Advanced Metabolic Engineering: From Foundational Principles to Next-Generation Platforms
Selecting an optimal microbial chassis is a critical, multi-faceted decision that determines the success of metabolic engineering projects aimed at biomanufacturing high-value therapeutics and chemicals.
Metabolic Engineering for Advanced Biofuels: Pathway Optimization, Novel Hosts, and Industrial Scale-Up
This article synthesizes current advancements and methodologies in applying metabolic engineering to biofuel production, tailored for researchers and scientists in biotechnology and drug development.
Engineering Secondary Metabolites in Plants and Microbes: Pathways, CRISPR, and Microbial Synthesis for Drug Discovery
This article provides a comprehensive overview of modern strategies for engineering the production of valuable secondary metabolites in plants and microbes.
Genome-Scale Metabolic Modeling: A Systems Biology Framework for Drug Discovery and Biomedical Innovation
This article provides a comprehensive introduction to Genome-Scale Metabolic Models (GEMs), computational tools that define gene-protein-reaction relationships for an organism's entire metabolic network.
Flux Balance Analysis for Strain Design: A Comprehensive Guide for Biomedical Researchers
This article provides a comprehensive guide to Flux Balance Analysis (FBA) and its critical role in metabolic engineering and strain design for biomedical applications.
Advanced Metabolic Engineering Strategies for Developing Microbial Cell Factories
This article provides a comprehensive overview of contemporary metabolic engineering strategies for developing efficient microbial cell factories, targeting researchers and scientists in drug development and industrial biotechnology.