Research Articles
Targeting LPS Synthesis: How CHIR-090 Inhibits LpxC to Combat Gram-Negative Pathogens and Mitigate Toxicity
This article provides a comprehensive analysis of CHIR-090 as a potent, slow-binding inhibitor of the essential enzyme LpxC in Gram-negative bacterial lipopolysaccharide (LPS) biosynthesis.
Metabolic Flux Analysis: Real-Time Biosensors vs. Gold-Standard Chromatography for Biomedical Research
This article provides a comprehensive comparative analysis of two primary methodologies for metabolic flux analysis (MFA) in biomedical research and drug development: dynamic, real-time biosensors and high-resolution, gold-standard chromatography.
The BiGG Models Knowledgebase: A Comprehensive Guide to Genome-Scale Metabolic Modeling for Biomedical Research
This article provides a complete guide to the BiGG Models knowledgebase, an essential resource for researchers constructing and analyzing genome-scale metabolic models (GEMs).
Comprehensive Guide to FBA Tools for Strain Design: 2024 Benchmarking for Researchers
This article provides a comprehensive benchmarking analysis of Flux Balance Analysis (FBA) tools for microbial strain design, tailored for researchers, scientists, and drug development professionals.
Bayesian vs. Conventional 13C-MFA: A Comprehensive Guide to Choosing the Right Flux Estimation Method for Biomedical Research
This article provides a detailed comparative analysis of Bayesian and conventional (frequentist) approaches to 13C-Metabolic Flux Analysis (13C-MFA) for researchers and drug development professionals.
Bayesian Model Averaging in 13C-MFA: A Robust Framework for Metabolic Network Selection and Uncertainty Quantification
This article provides a comprehensive guide to Bayesian Model Averaging (BMA) for model selection in 13C Metabolic Flux Analysis (13C-MFA).
Mastering the Equilibrium: Strategies for Balancing Growth and Production in Microbial Fatty Acid Biosynthesis
This article provides a comprehensive guide for researchers and drug development professionals on managing the critical balance between cellular growth and fatty acid production in engineered systems.
Metabolic Flux Imbalances in Lipid Pathways: Causes, Consequences, and Cutting-Edge Correction Strategies
This article provides a comprehensive analysis of metabolic flux imbalances in lipid synthesis, storage, and oxidation pathways.
Harnessing Acetyl-CoA and Malonyl-CoA: Metabolic Engineering for Advanced Biofuel Production
This article provides a comprehensive review of acetyl-CoA and malonyl-CoA as pivotal metabolic precursors for microbial biofuel synthesis.
ARTP Mutagenesis and FACS Screening: A High-Throughput Pipeline for Engineering Amino Acid Overproducers
This article provides a comprehensive guide to the integrated workflow of Atmospheric and Room Temperature Plasma (ARTP) mutagenesis and Fluorescence-Activated Cell Sorting (FACS) for the high-throughput selection of microbial strains...